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Indications: Wrinkles, expression lines, sagging skin, scars, discolorations, dull skin Information Category: Creams Concern: Antiage, Antioxidant, Fine Lines, Hydration, Lifting, Pigmentation, Rejuvenation, Repair Aging, Skin Barrier Protection, Wrinkles Skin Type: Dry, Mature, Normal Action The action mechanism of PDRN Rejuvenation Cream is based on: The multifaceted mechanism of action of PDRN polynucleotide The synergy of PDRN with the below targeted active ingredients to enhance and improve basic vital functions of the skin and its physiology: Peptides: Copper Tripeptide, Peptilift, Oligopeptide-51 Medium molecular weight Hyaluronic acid (MMW) Ceramides and moisture retention agents Vitamins: Vitamin B3 (Niacinamide), Vitamin E (Tocopherol)

The study medication was stored in a study refrigerator and protected from light until 30 min before administration, when it was allowed to come to room temperature, for participant comfort during administration

Mechanism 3 Direct Fat Cell Targeting (Lipolytic Pathway) Some peptides bypass appetite and hormonal pathways entirely and act directly on fat cells

Each can provides an excellent source of B vitamins, including 500% Daily Value of Vitamin B12, 260% of Riboflavin (B2), 250% of Niacin (B3), and 240% of Vitamin B6, which support energy metabolism

doi: 10.1038/s41580-020-0230-3 92 TrujilloJMolina-JijonEMedina-CamposONRodriguez-MunozRReyesJLLoredoMLet al